Endocrine Abstracts

Brain tumors are on the 3rd place in terms of growth rates of incidence among oncological diseases. By virtue of the improvement of neurosurgical treatment methods, with the use of modern chemotherapy and radiation therapy, the survival of patients with benign and malignant brain tumors is increasing. A significant proportion of patients with such tumors are young people of reproductive age who are interested in maintaining their fertility. Neurosurgical removal of tumors, whi...

Thyrotropinoma (TSH-secreting pituitary adenomas, TSH-AG) are rare tumor of the pituitary (0.5–2% of all pituitary adenomas). Localization of the tumor with the appropriate neuroendocrine disorders has features in the clinic. This is due to the direct damage to the nucleus and structures of the pituitary with hypersecretion of TSH, which leads to overstimulation of the thyroid gland and the emergence of the clinical picture of ‘central’ hyperthyroidism. Differen...

Introduction: Pituitary carcinomas are extremely rare neoplasms and molecular events leading to malignant pituitary transformation are largely unknown.Case report: 36-year-old man turned to the clinic for visual and oculomotor disorders. A large endo-supra-latero(S)sellar tumor was found on MRI. There was also an increase in the level of ACTH in the blood (60,80 pmol/l (normal values 5–49)). The level of free cortisol in 24-hour urine was normal. En...

The article presents a case of permanent central diabetes insipidus (CDI) in a patient after severe traumatic brain injury (TBI) in traffic accident. A 16-year-old boy entered to a medical facility in the coma (6 points of Glasgow Coma scale (GCS)). Diagnosis: acute TBI; severe cerebral contusion; subarachnoid hemorrhage; depressed comminuted cranial vault fracture; basilar skull fracture; visceral contusion. CDI diagnosed three days after injury when polyuria and hypernatremi...

Presented case demonstrates a rare diencephalic pathology — adipsic diabetes insipidus (ADI) with severe hypernatremia in a 58-year-old woman after ttranssphenoidal removal of stalk intraventricular craniopharyngioma. ADI was diagnosed because of hypernatremia (150–155 mmol/l), polyuria (up to 4 liters per day) and absence of thirst. Normalization of wa- ter-electrolyte balance occurred on the background of desmopressin therapy and sufficient hydration in postoperati...

Reset osmostat syndrome (ROS) is characterized by a change of normal plasma osmolality level (decrease or increase), which leads to chronic dysnatremia (hypo- or hypernatremia). We have described a Clinical case of ROS and chronic hyponatremia in a patient with chordoid glioma of the III ventricle. It is known that the patient had previously been diagnosed with hyponatremia (131-134 mmol/l). She has not hypothyroidism and hypocorticism. There is normal filtration function of t...

Objective: To analyze the remission factors of surgical treatment of acromegaly Methods: A retrospective study involving 227 patients with acromegaly: 143 (63%) women and 84 (37%) men were operated via trassphenoidal endoscopic approach for pituitary adenoma removal between the periods of 2018-2021. The average age was 45 years [36.00, 56.00]. 118 patients had 6 months follow-up period (3-40 months). The IGF-1 index used for the evaluation, which was cal...

The tumors of the thalamic-hypothalamic-pituitary system (diencephalon region, DR) include a fairly large group. These are pituitary adenomas, craniopharyngiomas (CP), pineal tumors, gliomas, meningiomas, and others. Tumors differ in the location, histological structure, and manifestations of the clinical picture with the corresponding hormonal changes, approaches and methods in treatment. Psychopathological symptoms are revealed in the symptoms of lesion of the DR in addition...